Genome Evolution, Biodiversity Genomics, Bioinformatics

 

The Lewin Lab studies how mammalian genomes evolve and the role of chromosome rearrangements in adaptation, speciation, and the origins of cancer. We have recently developed a powerful new algorithm for assembling genomes that do not have physical or genetic maps using next generation sequencing data and phylogenetic inference, thus opening the door to large-scale multi-species genome comparisons, including those of primates. These studies have shed light on the chromosome rearrangements and genes within evolutionary breakpoint regions that are related to lineage and species-specific adaptations.